Treatment of early dementia with antibiotics possible: research


Frontotemporal dementia is the most common type of early dementia, usually beginning between the ages of 40 and 65. It affects the frontol and temporal lobe of the brain, causing behavioral changes, difficulty speaking and writing, and memory decline.

According to a research published in Human Molecular Genetics, a subgroup of patients with frontotemporal dementia has a specific genetic mutation. It prevents the brain cells from making progranulin protein.

Although progranulin has not been widely understood, its absence is directly related to the disease.
Researchers at the US-based University of Kentucky found that after the addition of aminoglycoside antibiotics to neuronal cells with this mutation, the cells gave up the mutation and started making full-length progranulin proteins.


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